Transcript Related Guidelines

Is There Still a Role for AuSCT in AML?

Adriano Venditti, MD · Tor Vergata University of Rome


October 08, 2020

This transcript has been edited for clarity.  

Autologous stem cell transplantation has been for a long time considered a possible option for treating patients with acute myeloid leukemia after consolidation therapy. Actually, this is quite a long and controversial affair. The very initial results published by the NCRI (National Cancer Research Institute) group almost 20 years ago demonstrated no benefit from the autologous stem cell transplant option for patients with acute myeloid leukemia. 

More recently, the HOVON-SAKK (The Dutch-Belgian Hemato-Oncology Cooperative Group and the Swiss Group for Clinical Cancer Research) group published in 2011, more precisely, a study that investigated in a randomized fashion the role of autologous stem cell transplant in acute myeloid leukemia.[1] In this very large series of patients, the Dutch colleagues found that indeed there was a benefit for patients from the autologous stem cell transplant option.[2] I have to say that more recently, the European LeukemiaNet recommendation actually found that there is still room for autologous stem cell transplant in very, very selected situations—for instance, patients belonging to the intermediate category who achieve after consolidation an MRD (minimal residual disease)-negative complete remission.[3,4,5] 

So, these recommendations are quite relevant in this statement. Because on one side, they reinforce the role of autologous stem cell transplant again in select situations. On the other side, they emphasize the role of minimal residual disease detection. Actually, MRD assessment can be a sort of driver whether or not to address patients to an autologous stem cell transplant option.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.
Post as: